Events

CBS Seminar: Dan Whitcomb- The effects of ultrasound neuromodulation at the cellular and molecular level

We are pleased to invite you to this CBS Seminar with Daniel Whitcomb, Senior Lecturer in Translational Neuroscience at the University of Bristol.

Event details

Abstract

Focused ultrasound stimulation (FUS) is now established as a major non-invasive neuromodulator for experimental and therapeutic purposes. But how exactly does FUS exert its effects? Our work centres on understanding the cellular and molecular mechanisms that underpin neuromodulation by ultrasound. In our two recent publications (Clennell et al., 2021. Brain Stimul. 14(2):217-225; Clennell et al., 2023. Brain Stimul. 16(2):540-552), we described how transient ultrasound exposure leads to rapid changes in the intrinsic excitability properties of cortical neurons, and that these effects are initiated at the synapse. In our recent unpublished work, we now find that these effects extend beyond single cells, with consequences for neural circuitry that may have important implications in using FUS to modulate cognition, in healthy and disease states.

This will be a hybrid seminar with the speaker presenting live in-person in South Cloisters, room 2.13, St Luke’s Campus.

There is also the option join virtually via Zoom: 

https://Universityofexeter.zoom.us/j/96164433450?pwd=cEtyYmNBcTVna0RXa25Lb210em5Tdz09

Meeting ID: 961 6443 3450 Password: 176157

A drinks reception with non-alcoholic drinks and nibbles will also be provided at the seminar. Please feel free to forward this invitation to colleagues and networks.  

Event: Wednesday 19th June 1:00- 2:30pm South Cloisters, room 2.13, St Luke’s Campus

Title: The effects of ultrasound neuromodulation at the cellular and molecular level

Bio: Daniel is a Senior Lecturer in Translational Neuroscience (Bristol Medical School, University of Bristol). Having completed a PhD in Neuroscience (University of Bristol) determining mechanisms of aberrant synaptic plasticity in Alzheimer’s disease pathology, Daniel went on to characterise cellular and molecular processes underlying synapse loss in the disease during a Post-Doctoral Research Associate position (Wellcome Trust/Medical Research Council Neurodegenerative Initiative Program). Daniel’s research now centres on understanding the molecular mechanisms that underpin neuromodulation by ultrasound, and how these effects can be leveraged for therapeutic benefit.

 

Location:

South Cloisters 2.13