Publications
Ka Kiu Lee, Urszula Łapińska, Giulia Tolle, Wanida Phetsang, Anthony D Verderosa, Brandon M Invergo, Joseph Westley, Attila Bebes, Raif Yuecel, Paul A O’Neill, Audrey Farbos, Aaron R Jeffries, Stineke van Houte, Pierluigi Caboni, Mark AT Blaskovich, Benjamin E Housden, Krasimira Tsaneva-Atanasova, Stefano Pagliara. Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides. eLife (2024).
Malamud M, Whitehead L, McIntosh A, Colella F, Roelofs AJ, Kusakabe T, Dambuza IM, Phillips-Brookes A, Salazar F, Perez F, Shoesmith R, Zakrzewski P, Sey EA, Rodrigues C, Morvay PL, Redelinghuys P, Bedekovic T, Fernandes MJG, Almizraq R, Branch DR, Amulic B, Harvey J, Stewart D, Yuecel R, Reid DM, McConnachie A, Pickering MC, Botto M, Iliev ID, McInnes IB, De Bari C, Willment JA, Brown GD. Recognition and control of neutrophil extracellular trap formation by MICL. Nature (2024 Aug 14). doi: 10.1038/s41586-024-07820-3.
Martino D, Kresoje N, Amenyogbe N, Ben-Othman R, Cai B, Lo M, Idoko O, Odumade OA, Falsafi R, Blimkie TM, An A, Shannon CP, Montante S, Dhillon BK, Diray-Arce J, Ozonoff A, Smolen KK, Brinkman RR, McEnaney K, Angelidou A, Richmond P, Tebbutt SJ; EPIC-HIPC consortium; Kampmann B, Levy O, Hancock REW, Lee AHY, Kollmann TR. DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life. Nat Commun. 2024 Sep 17;15(1):8167. doi: 10.1038/s41467-024-52283-9. PMID: 39289350; PMCID: PMC11408723.
Montante S, Ben-Othman R, Amenyogbe N, Angelidou A, van den Biggelaar A, Cai B, Chen Y, Darboe A, Diray-Arce J, Ford R, Idoko O, Lee A, Lo M, McEnaney K, Malek M, Martino D, Masiria G, Odumade OA, Pomat W, Shannon C, Smolen K, Consortium TE, Ozonoff A, Richmond P, Tebbutt S, Levy O, Kampmann B, Brinkman R, Kollmann T. Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human Life. J Immunol Res. 2024 Jul 23;2024:1117796. doi: 10.1155/2024/1117796. PMID: 39081632; PMCID: PMC11288693.
G Mozo E, Ross O, Yuecel R, Dambuza IM, Mukaremera L. Human plasma-like medium (HPLM) induces Cryptococcus neoformans in vivo cell morphologies. mSphere (2024) Jun 25;9(6)
Houlder, E. L., Gago, S., Vere, G., Conn, D., Khan, S., Thomson, D., Shepherd, M., Lebedinec, R., Brown, G. D., Bromley, M. Aspergillus-mediated allergic airway inflammation is triggered by dendritic cell recognition of a defined spore morphotype, a process that can be targeted via antifungal therapeutics. bioRxiv (2024), pp. 2024–01.
Damianou, A., Liang, Z., Lassen, F., Vendrell, I., Vere, G., Hester, S., Charles, P. D., Pinto-Fernandez, A., Santos, A., Fischer, R. Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex. Life Science Alliance 7.5 (2024).
Campbell JS, Pearce JC, Bebes A, Pradhan A, Yuecel R, Brown AJP, Wakefield JG. Characterising phagocytes and measuring phagocytosis from live Galleria mellonella larvae. Virulence. 2024 Dec;15(1):2313413. doi: 10.1080/21505594.2024.2313413.
Arita GS, Ma Q, Leaves I, Pradhan A, Hickey E, Dambuza I, Bebes A, Vincenzi Conrado PC, Barros Galinari C, Vicente Seixas FA, Kioshima ÉS, de Souza Bonfim-Mendonça P, Svidzinski TIE, Brown AJP. The impact of ORF19.36.1 in the pathobiology of Candida albicans. Microb Pathog. 2023 Dec;185:106437.
Earle, K., Valero, C., Conn, D. P., Vere, G., Cook, P. C., Bromley, M. J., Bowyer, P., and Gago, S. Pathogenicity and virulence of Aspergillus fumigatus. Virulence 14.1 (2023), p. 2172264.
King J, Dambuza IM, Reid DM, Yuecel R, Brown GD, Warris A. Detailed characterisation of invasive aspergillosis in a murine model of X-linked chronic granulomatous disease shows new insights in infections caused by Aspergillus fumigatus versus Aspergillus nidulans. Front Cell Infect Microbiol. 2023 Sep 1;13:1241770
Montante S, Chen Y, Brinkman RR. flowSim: Near duplicate detection for flow cytometry data. Cytometry A. 2023 Nov;103(11):889-901. doi: 10.1002/cyto.a.24776. Epub 2023 Aug 29. PMID: 37530476; PMCID: PMC10834853.
Avelar GM,, …Yuecel, R…. Brown AJP. Impact of changes at the Candida albicans cell surface upon immunogenicity and colonisation in the gastrointestinal tract. Cell Surf. 2022 Oct 17;8:100084
Vere, G., Alam, M. R., Farrar, S., Kealy, R., Kessler, B. M., O’Brien, D. P., and Pinto-Fernandez, A. Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19. Biomolecules 12.2 (2022), p. 300.
de Assis, LJ, …Yuecel, R…. Brown AJP. Nature of β-1,3-Glucan-Exposing Features on Candida albicans Cell Wall and Their Modulation. mBio, 2022 Oct 11;e0260522.
Stappers MHT, Nikolakopoulou C, Wiesner DL, Yuecel R, Klein BS, Willment JA, Brown GD Characterization of antifungal C-type lectin receptor expression on murine epithelial and endothelial cells in mucosal tissues. Eur J Immunol. 2021, 51(9):2341-2344
Tone K, Stappers MHT, Hatinguais R, Dambuza IM, Salazar F, Wallace C, Yuecel R, Morvay PL, Kuwano K, Willment JA, Brown GD (2021) MelLec Exacerbates the Pathogenesis of Aspergillus fumigatus-Induced Allergic Inflammation in Mice. Front Immunol. 2021 May 28;12:675702
Pinto-Fernandez, A., Salio, M., Partridge, T., Chen, J., Vere, G., Greenwood, H., Olie, C. S., Damianou, A., Scott, H. C., Pegg, H. J. Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity. British Journal of Cancer 124.4 (2021), pp. 817–830.
Ruiz, E. J., Pinto-Fernandez, A., Turnbull, A. P., Lan, L., Charlton, T. M., Scott, H. C., Damianou, A., Vere, G., Riising, E. M., Da Costa, C. USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma. Elife 10 (2021), e71596.
Laurentino TG, Xavier M, Ronco F, Pina-Martins F, Domingues IL, et al. (2021) “evALLution: making basic evolution concepts accessible to people with visual impairment through a multisensory tree of life.” Evo Edu Outreach 14, 5.
Comandatore F, Radaelli G, Montante S, Sacchi L, Clementi E, Epis S, Cafiso A, Serra V, Pajoro M, Di Carlo D, Floriano AM, Stavru F, Bandi C, Sassera D. Modeling the Life Cycle of the Intramitochondrial Bacterium "Candidatus Midichloria mitochondrii" Using Electron Microscopy Data. mBio. 2021 Jun 29;12(3):e0057421. doi: 10.1128/mBio.00574-21. Epub 2021 Jun 22. PMID: 34154402; PMCID: PMC8262999.
Vere, G., Kealy, R., Kessler, B. M., and Pinto-Fernandez, A. “Ubiquitomics: an overview and future”. Biomolecules 10.10 (2020), p. 1453
Schaefer K, Dambuza IM, Dall'Angelo S, Yuecel R, Jaspars M, Trembleau L, Zanda M, Brown GD, Netea MG, Gow NAR. A Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential Biosecurity Risk in the Retrieval of Exo-Microorganisms. Microorganisms 2020, 8(7):1066
Haydn FT, Yuecel R and Gutierrez T (2020) Hydrocarbon-Degrading Bacteria Found Tightly Associated with the 50–70 μm Cell-Size Population of Eukaryotic Phytoplankton in Surface Waters of a Northeast Atlantic Region Microorganisms 2020, 8(12): 1955
Ballard E, Yucel R, Melchers WJG, Brown AJP, Verweij PE, Warris A (2020) Antifungal Activity of Antimicrobial Peptides and Proteins against Aspergillus fumigatus. J Fungi (Basel). May 18;6(2):65
Abbas, H, Broche, LM, Ezdoglian A, Li, D, Yuecel, R, Ross, PJ, Cheyne, L, Wilson, HM, Lurie, DJ, Dawson DK (2020), Fast field-cycling magnetic resonance detection of intracellular ultra-small iron oxide particles in vitro: Proof-of-concept J Magn Reson, 313: 106722
Belső N, Gubán B, Manczinger M, Kormos B, Bebes A, Németh I, Veréb Z, Széll M, Kemény L, Bata-Csörgő Z. Differential role of D cyclins in the regulation of cell cycle by influencing Ki67 expression in HaCaT cells. Exp Cell Res. 2019 Jan 15;374(2):290-303.
Li, D, Roca, M, Yuecel, R and Lorenz, A (2019) Immediate visualization of recombination events and chromosome segregation defects in fission yeast meiosis. Chromosoma, p1-12
Damiani E, Yuecel R, Wallace HM (2019), Repurposing of idebenone as a potential anti-cancer agent. Biochem J. 25;476(2)
Montante S, Brinkman RR. Flow cytometry data analysis: Recent tools and algorithms. Int J Lab Hematol. 2019 May;41 Suppl 1:56-62. doi: 10.1111/ijlh.13016. PMID: 31069980.
Scally, C., Abbas, H.,… Yuecel, R., … & Dawson, D. K. (2019) Myocardial and Systemic Inflammation in Acute Stress-Induced (takotsubo) Cardiomyopathy. Circulation, 139:1581–1592
Dambuza,I, Drake, T, Taylor-Smith, Chapuis, A, LeGrave, N, Rasmussen, T, Fisher, MC, Bicanic, T, Harrison, T, Jaspars, M, May, R, Brown, GD, Yuecel, R, MacCallum, DM, and Ballou, ER (2018), The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis. PLoS Pathogens. 14 (5)
Stappers, MHT, Clark, AE,... Yuecel, R, ...and Brown, GD (2018), Recognition of DHN-melanin by the C-type lectin, MelLec, is required for protective immunity to Aspergillus fumigatus. Nature 555, 382–386
Domingues IL, Gama J, Carvalho LM, Dionisio F. (2017). “Social behaviour involving drug resistance: the role of initial density, initial frequency and population structure in shaping the effect of antibiotic resistance as a public good” Heredity 119:295–301.
Pradhan A, Herrero-de-Dios C, Belmonte R, Budge S, Lopez Garcia A, Kolmogorova A, Lee KK, Martin BD, Ribeiro A, Bebes A, Yuecel R, Gow NAR, Munro CA, MacCallum DM, Quinn J and Brown AJP (2017), Elevated catalase expression in a fungal pathogen is a double-edged sword of iron. PLoS Pathog. 22;13(5)
Collins C, Hall M, Bruno D, Sokolowska J, Duncan L, Yücel R, McCarthy U, Fordyce MJ, Pert CC, McIntosh R and MacKay Z (2017), Generation of Paramoeba perurans clonal cultures using flow cytometry and confirmation of virulence. J Fish Dis. 40:351-365.
Gubán B, Vas K, Balog Z, Manczinger M, Bebes A, Groma G, Széll M, Kemény L, Bata-Csörgő Z. Abnormal regulation of fibronectin production by fibroblasts in psoriasis. Br J Dermatol. 2016 Mar;174(3):533-41.
Mukhopadhya, I, Murray, GI, Yuecel , R, Duncan, L, Shattock, R, Kelly, C, Iannelli, F, Pozzi, G, El-Omar, EM, Hold, GL and Hijazi, K (2016), Transporters for antiretroviral drugs in colorectal CD4+ T cells and circulating α4β7 integrin CD4+ T cells: Implications for HIV microbicides. Mol Pharm. 13:3334-40.
Sutherland AG, Cook A, Miller C, Duncan L, Yuecel R, Heys SD, Hutchison JD and Liversidge J (2015), Older Patients Are Immunocompromised by Cytokine Depletion and Loss of Innate Immune Function After HIP Fracture Surgery. Geriatr Orthop Surg Rehabil. 6:295-302.
Liversidge, L, Yuecel , R, Forrester, M, Yeoh, J, Wallace, C, Keech, F, Reid, DM, and Basu, N (2014), Positive correlation between IL-23 and response to anti-TNF-alpha therapy in RA patients resistant to conventional therapy. BSI Abstract, Immunology 143:150-150
Fazekas B, Polyánka H, Bebes A, Tax G, Szabó K, Farkas K, Kinyó A, Nagy F, Kemény L, Széll M, Ádám É. UVB-dependent changes in the expression of fast-responding early genes is modulated by huCOP1 in keratinocytes. J Photochem Photobiol B. 2014 Nov;140:215-22.
Bebes A, Kovács-Sólyom F, Prihoda J, Kui R, Kemény L, Gyulai R. Interleukin-1 receptors are differentially expressed in normal and psoriatic T cells. Mediators Inflamm. 2014;2014:472625.
Szabó K, Bata-Csörgő Z, Dallos A, Bebes A, Francziszti L, Dobozy A, Kemény L, Széll M. Regulatory networks contributing to psoriasis susceptibility. Acta Derm Venereol. 2014 Jul;94(4):380-5.
Gama J A, Reis AM, Domingues IL, Mendes-Soares H, Matos AM, Dionisio, F. (2013). Temperate bacterial viruses as double-edged swords in bacterial warfare. PLoS One 8(3).
Bebes A, Kis K, Nagy T, Kurunczi A, Polyánka H, Bata-Csörgo Z, Kemény L, Dobozy A, Széll M. The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related. Arch Dermatol Res. 2012 Jan;304(1):57-63.
Tokés T, Eros G, Bebes A, Hartmann P, Várszegi S, Varga G, Kaszaki J, Gulya K, Ghyczy M, Boros M. Protective effects of a phosphatidylcholine-enriched diet in lipopolysaccharide-induced experimental neuroinflammation in the rat. Shock. 2011 Nov;36(5):458-65.
Bebes A, Nagy T, Bata-Csörgo Z, Kemény L, Dobozy A, Széll M. Specific inhibition of the ABCG2 transporter could improve the efficacy of photodynamic therapy. J Photochem Photobiol B. 2011 Nov 3;105(2):162-6.
Kormos B, Belso N, Bebes A, Szabad G, Bacsa S, Széll M, Kemény L, Bata-Csörgo Z. In vitro dedifferentiation of melanocytes from adult epidermis. PLoS One. 2011 Feb 23;6(2):e17197.
Secenji M, Hideg E, Bebes A, Györgyey J. Transcriptional differences in gene families of the ascorbate-glutathione cycle in wheat during mild water deficit. Plant Cell Rep. 2010 Jan;29(1):37-50.
Kinyó A, Kiss-László Z, Hambalkó S, Bebes A, Kiss M, Széll M, Bata-Csörgo Z, Nagy F, Kemény L. COP1 contributes to UVB-induced signaling in human keratinocytes. J Invest Dermatol. 2010 Feb;130(2):541-5.
Pargmann, D, Yücel, R, Kosan, C, Klein-Hitpass, L, Schimmer, S, Dittmer, D and Möröy, T (2007), Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function. Eur J Immunol. 37:3551-63.
Geh, S. Höhr, D, Borm, P-JA, Duffin, R, Yücel, R, Armbruster, L, Raulf-Heimsoth, M, Brüning, T, Hoffmann, E, Rettenmeier, AW and Dopp, E (2006), Cellular uptake and cytotoxic potential of respirable bentonite particles with different quartz contents and chemical modifications in human lung fibroblasts. Arch Toxicol 80:98-106.
Rathinam, C, Geffers, R, Yücel, R, Buer, J, Welte, K, Möröy, T and Klein, C (2005) , The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and –function. Immunity 22:717-28.
Zeng, H, Yücel, R, Kosan, C, Klein-Hitpass, L and Möröy, T (2004), Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J 23:4116-25.
Hertzano, R, Montcouquiol, M,Rashi-Elkeles, S, Elkon, R, Yücel, R, Frankel, WF, Rechavi, G, Möröy T, Friedman, TB, Kelley, MW and Avraham, KW (2004) Transcription profiling of inner ears from Pou4f3ddl/ddl identifies Gfi1 as a target of the Pou4f3 deafness gene. Hum Mol Genet 13:2143-53.
Yücel, R, Kosan, C, Heyd, F and Möröy, T (2004) Gfi1:GFP knock-in mutant reveals differential expression and auto-regulation of the gene Growth factor independence 1 (Gfi1) during lymphocyte development. J Biol Chem 279:40906-17.
Yücel, R, Karsunky, H, Klein-Hitpass, L and Möröy, T (2003) The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus. J Exp Med 197:831-44.
Geisen, C, Karsunky, H, Yücel, R and Möröy, T (2003) Loss of p27(Kip1) cooperates with cyclin E in T-cell lymphomagenesis. Oncogene 22:1724-9.
Molenaar, D, van der Rest, ME, Drysch, A and Yücel, R (2000), Functions of the membrane-associated and cytoplasmic malate dehydrogenases in the citric acid cycle of Corynebacterium glutamicum. J Bacteriol 182:6884-91.
