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Pharmacology and Medicinal Chemistry

Module description

This module offers you an insight into the design of drug molecules, the biological macromolecules they are designed to target and their mode of action. It covers a broad area of the subject from the chemical design to allow molecules to get to their target in the human or bacterial cell, the biological targets and mode of action and their medical application. It will be of invaluable experience for those wanting to pursue a career in medicine or medically related research. It will also be of interest to those wanting to work in the pharmaceutical or medically related biotechnology industries.

Module aims - intentions of the module

This module aims to introduce you to the biological and chemical aspects of pharmacology using known examples of commonly used drugs and anti-microbial compounds. This will be integrated with medicinal chemistry considerations and will cover the factors involved in drug discovery from initial lead compounds to the final drug launch. The latter part of the course will expose you to current knowledge of several important human diseases including HIV, and COVID-19.

Intended Learning Outcomes (ILOs)

ILO: Module-specific skills

On successfully completing the module you will be able to...

• 1. Discuss the basic concepts of pharmacology and illustrate how several major groups of drugs have been discovered and developed
• 2. Explain and critically evaluate all aspects of the drug discovery process, particularly from lead compound discovery to the optimisation of biological activity.
• 3. Analyse important human diseases and critically assess current therapeutic approaches

ILO: Discipline-specific skills

On successfully completing the module you will be able to...

• 4. Analyse and evaluate independently a range of research-informed literature, and synthesise research-informed examples from the literature into written work
• 5. Deploy established techniques of data analysis and enquiry

ILO: Personal and key skills

On successfully completing the module you will be able to...

• 6. Effectively communicate arguments, evidence and conclusions using written and oral means in a manner appropriate to the intended audience
• 7. Develop, a logical and reasoned argument with sound, convincing conclusions
• 8. Analyse and evaluate appropriate data with very limited guidance

Syllabus plan

Introduction to the biological macromolecules where drugs interact in the body i.e. lipids, protein receptors and enzymes and nucleic acids. The current knowledge of drug/macromolecular interactions will be reviewed. Topics covered include: pharmacokinetics, the pharmacology of receptors, neurotransmitters in the central nervous system, the measurement of agonist and antagonist activity and drug access and prodrugs.

The module examines the discovery of new drugs starting from natural products, through optimisation of biological activity ("rule of five"), pharmacokinetics and QSAR to clinical trials. Examples will be given from many different drug classes. Combinatorial and computer-based methods for drug discovery will be briefly introduced.

The current status and future impact of molecular biology in drug discovery will be addressed and major groups of drugs such as antimicrobials, morphine analogues and antivirals are studied in detail. Lectures will consider the disease process and current therapy used for their treatment.

Learning activities and teaching methods (given in hours of study time)

Details of learning activities and teaching methods

Formative assessment

Summative assessment (% of credit)

Details of summative assessment

Details of re-assessment (where required by referral or deferral)

Re-assessment notes

Deferral – if you miss an assessment for certificated reasons that are approved by the Mitigation Committee, you will normally be either deferred in the assessment or an extension may be granted. If deferred, the format and timing of the re-assessment for each of the summative assessments is detailed in the table above ('Details of re-assessment'). The mark given for a deferred assessment will not be capped and will be treated as it would be if it were your first attempt at the assessment.

Referral - if you have failed the module (i.e. a final overall module mark of less than 40%) and the module cannot be condoned, you will be required to complete a re-assessment for each of the failed components on the module. The format and timing of the re-assessment for each of the summative assessments is detailed in the table above ('Details of re-assessment'). If you pass the module following re-assessment, your module mark will be capped at 40%.

Indicative learning resources - Basic reading

• Patrick, An Introduction to Medicinal Chemistry,7^th Edition 2023 Oxford University Press, ISBN 978-0-19-8866664.

Indicative learning resources - Web based and electronic resources

• Module-specific ELE page

Key words search

Drug design, drug target, medicinal therapeutics