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Medical Mycology

Module description

Fungal pathogens have a major impact on human health, killing as many people as malaria each year. This Medical Mycology module will provide you with insight into the key concepts relating to human fungal pathogenesis, from fungal virulence to immune defences and patient susceptibility. It will describe the biology of fungal pathogens (including the mechanisms that promote colonisation and infection), how our immune system combats these infections, antifungal drugs and diagnostics used by clinicians, and the problem of emerging antifungal drug resistance.

This module is taught by members of the Medical Research Council Centre for Medical Mycology.

Module aims - intentions of the module

The main aim of this module is to provide you with an understanding of fundamental principles in medical mycology and fungal immunology. After an introduction to key concepts in the field, you will be taught about the nature of fungal infections, state-of-the-art research approaches that are being applied to dissect molecular mechanisms underlying fungal pathogenesis, the processes that underlie antifungal immunity, and how fungal infections are treated in the clinic. The module will also provide basic training in aseptic technique, safe handling and culture of pathogenic fungi, molecular tools, immunology, cytometry and bioinformatics tools. In addition to learning about this clinically important field, you will engage with original research literature, develop research level critical thinking skills in medical mycology and fungal immunology, and learn to communicate complex ideas to both groups and individuals.

Intended Learning Outcomes (ILOs)

ILO: Module-specific skills

On successfully completing the module you will be able to...

• 1. Critically discuss a variety of types of fungal disease, their impact on human health, and how they are diagnosed and treated.
• 2. Outline and critically evaluate the mechanisms by which a range of different fungal pathogens cause disease in humans, including their virulence factors and fitness attributes, including an understanding of how immune cells recognise fungal pathogens and clear them from host tissues.
• 3. Summarise bioinformatic, genomic, genetic, molecular, cellular and immunological approaches that are currently employed to research fungal pathogenesis and immunology.

ILO: Discipline-specific skills

On successfully completing the module you will be able to...

• 4. Demonstrate competency in a range of mycological research methods, and show understanding of how those methods are applied in microbiological research.
• 5. Collect and/or interpret quantitative data, including the application of relevant statistical methods.
• 6. Demonstrate competency in the reading and interpretation of primary scientific literature.

ILO: Personal and key skills

On successfully completing the module you will be able to...

• 7. Demonstrate the ability to link and evaluate ideas from different sources to reach evidence-based and independent conclusions.
• 8. Employ different communication styles to communicate effectively to the target audience, including effective academic and scientific writing.

Syllabus plan

This module will explore the following topics in medical mycology via a combination of lectures, research seminars and video demonstrations that include data for analysis and interpretation:

• Fungal pathogens, disease and antifungal therapies
• Fungal virulence and fitness
• Antifungal immunity
• Research approaches in fungal pathogenesis
• Research approaches in antifungals

In addition, you will deliver assessed reports on data handling/interpretation and an assessed critical essay on a selected topic in medical mycology.

Accessibility statement:
As part of this module, you will undertake laboratory sessions. The practical work will be undertaken in pairs, and sessions will frequently involve fine laboratory work, use of Bunsen burners and handling of live microbes. The practical sessions are of 4-hour duration, but breaks are possible, and students are able to leave the laboratory for short periods. Please contact the module convenor if you require any particular support within practical sessions.

Learning activities and teaching methods (given in hours of study time)

Details of learning activities and teaching methods

Formative assessment

Summative assessment (% of credit)

Details of summative assessment

Details of re-assessment (where required by referral or deferral)

Re-assessment notes

Deferral – if you miss an assessment for certificated reasons that are approved by the Mitigation Committee, you will normally be either deferred in the assessment or an extension may be granted. If deferred, the format and timing of the re-assessment for each of the summative assessments is detailed in the table above ('Details of re-assessment'). The mark given for a deferred assessment will not be capped and will be treated as it would be if it were your first attempt at the assessment.

Referral - if you have failed the module (i.e. a final overall module mark of less than 50%) and the module cannot be condoned, you will be required to complete a re-assessment for each of the failed components on the module. The format and timing of the re-assessment for each of the summative assessments is detailed in the table above ('Details of re-assessment'). If you pass the module following re-assessment, your module mark will be capped at 50%.

Indicative learning resources - Basic reading

• Primary research literature and review articles chosen by the module co-ordinators and students as required.
• Casadevall A et al. Human Fungal Pathogens Cold Spring Harbour Laboratory Press (2015)

Indicative learning resources - Web based and electronic resources

• Exeter Learning Environment (ELE)
• MRC CMM:http://biosciences.exeter.ac.uk/medicalmycology/

Indicative learning resources - Other resources

• Exeter Learning Environment (ELE) - https://ele.exeter.ac.uk/
• MRC CMM: https://www.exeter.ac.uk/research/medicalmycology/

Key words search

Medical mycology, fungal disease, pathogenicity, virulence, antifungal immunity, antifungal drugs, infection